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The Norwegian version of the hospital anxiety and depression scale (HADS) is a 14-item scale. Each item is scored 0 to 3, giving a sum between 0 and 21, with higher score indicating Estradiol Valerate and Estradiol Valerate Dienogest Tablets (Natazia)- FDA the symptoms are more severe. Half of the items represent an anxiety scale (HADS-A, items 1, 3, 5, 7, 9, 11 and 13) and the other half a depression scale (HADS-D, items 2, 4, 6, 8, 10, 12 and 14).

The score may be used as a total score (all items), as well as separate anxiety and depression scores. In the hospitalised older patients, the internal consistency reliability assessed by Cronbach's alpha was 0. Cronbach's alpha for subscales were: HADS-A 0. The AUDIT has a 10-item list giving a total score of 40, with score above 8 indicating problematic use. We used the Norwegian version of AUDIT. In a review, Cronbach's alpha ranged from 0.

We chose to exclude patients with MMSE score IBM SPSS statistics software (IBM Corp, released 2015, IBM SPSS Statistics for Windows, V. Armonk, New York, USA) was used for the analyses. The distribution of continuous variables was assessed by graphically inspecting the histograms (Cognistat, MMSE, clock, TMT A and B, education, age, HADS, CIRS-G triggered AUDIT).

Categorical variables (gender and smoking) were described by frequencies and percentages, whereas continuous variables were described by means (M), median, range or SD. Secondary outcomes were mean scores of the routine tests-MMSE, clock and TMT A and B.

Bivariate linear regression models were estimated to assess the relationship between the main and secondary outcomes, and CNSD use versus non-use. Two multiple linear regression models were estimated for each outcome. Both models were adjusted for the variables gender, age at baseline and education, and included the main covariates: HADS and CIRS-G total score. Model 1 contained CNSD use versus non-use, age, education and HADS total score.

As the construct of HADS and CIRS-G partially overlap, they were not included in the same model. Thus, in model 2, HADS total score was replaced by CIRS-G. Assumptions of linear regression models were assessed by using standard tests. An interaction model was performed between medication use and CIRS-G below (5. We performed two explorative Estradiol Valerate and Estradiol Valerate Dienogest Tablets (Natazia)- FDA hoc tests to examine associations between CNSD use versus non-use, and subdomains of Cognistat.

Finally, an additional explorative post hoc analysis was performed approved examine the differences in Cognistat by medication groups.

The results are presented in a bivariate analysis, not adjusted for confounder due to small sample size among some of the medication groups. All missing data are given in the table footnotes. A user advisory board established Estradiol Valerate and Estradiol Valerate Dienogest Tablets (Natazia)- FDA the Akershus University Hospital, Health Services Research Unit, which includes both representatives of patients and health service officials, supported this study.

The Estradiol Valerate and Estradiol Valerate Dienogest Tablets (Natazia)- FDA met on a regular basis throughout the study period. They provided feedbacks on the current project regarding the ethics, design and methodology.

Thirty per cent used more than one medication group (mostly opioids and Z-hypnotics). Most were long-term users of their CNSD medications, with overall median duration of use of 52 weeks (min: 4, max: 988). The demographic characteristics of the study sample are shown in table 1. Their mean age was 77. This indicates similar pattern in age and department of admission between non-participating sample compared with the participating sample.

To examine the different subdomains of Cognistat and their effect on CNSD user versus non-users, an explorative post hoc analysis was conducted by performing bivariate and multiple linear regression modelling, using the same models as for the main outcome.

Cognitive subdomain in Cognistat.

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